TABLE I.
Kinase inhibitor | Conc. | Kinase specificity | Ki or IC50 | Nuclear ferritin |
---|---|---|---|---|
Herbimycin A | 10 μM | p60 tyrosine kinase | 12 μM (IC50) | + |
PD153035 | 1 μM | EGFR tyrosine kinase | 6 pM (Ki) | + |
PD98059 | 10 μM | MEK (p42 MAPKK) | 2 μM (IC50) | + |
SB203580 | 1 μM | p38 MAP kinase | 600 nM (IC50) | + |
TBB | 1 μM | Casein kinase 2 | 900 nM (IC50) | + |
KT5720 | 1 μM | PKA | 56 nM (Ki) | + |
H-89 | 30 μM | PKA/PKC | 50 nM/32 μM (Ki) | − |
Bisindolylmaleimide-I | 10 nM | PKC | 10 nM (IC50) | − |