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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Obesity (Silver Spring). 2015 Dec 10;24(1):172–183. doi: 10.1002/oby.21354

Figure 8. ATM-derived IGF1 is required to maintain perigonadal adipose tissue during a cold challenge in obese animals.

Figure 8

(A) Body temperature of 46-week-old control (white diamonds) and Mac-IKO mice (filled circles) during a cold challenge at 4 °C (n= 8–15). (B) PGAT, and SCAT weights of cold challenged 46-week-old male obese mice. (C) Liver weight of cold challenged 46-week-old obese mice (D) PGAT histology, (E) adipocyte size distribution and (F) adipocyte number of PGAT from 46-week-old male obese mice following a cold challenged for 3 hours at 4 ° C. (G) 9-week old lean male mice were placed at either 25°C or 4°C for 72 hours and F4/80+ macrophage and adipocytes were purified. Expression of Igf1 and Tyrosine Hydroxylase (Th) were measured qPCR (n=10 per genotype), *p-value<0.05 relative to F4/80+ cells. All data are presented as means + SD. *p-value <0.05.