Table 1.
In vivo pharmacokinetic parameters of 7,8-DHF (p.o. 50 mg/kg)
| Cerep compound ID (dosed) | Client compound ID (dosed) | Route of administration | Dose mg/kg | |||||
|---|---|---|---|---|---|---|---|---|
| 100002126-1 | 7,8-DHF | p.o. | 50 | |||||
|
| ||||||||
| Cerep compound ID (detected) | Client compound ID (detected) | Subject | Tmax min | Cmax ng/ml | T1/2 min | AUClast1 min·ng/ml | AUCInf1 min·ng/ml | Terminal point |
|
| ||||||||
| 100002126-1 | 7,8-DHF | mice | 10 | 70 | 134 | 6,500 | 7,515 | 7 |
| 100002126-2 | 8-hydroxy-7-methoxyflavone | mice | 10 | 1 | 92 | 80 | 100 | 5 |
Pharmacokinetic parameters were derived from the noncompartmental model using WinNonlin 5.2.
Tmax = Time of maximum observed concentration; Cmax = concentration corresponding to Tmax; T1/2 = elimination half-life; AUClast = area under the concentration-time curve from the time of dosing to the time of last observation that is greater than the limit of quantitation; AUCInf = area under the concentration-time curve from the time of dosing, extrapolated to infinity; terminal point = number of observations used to calculate the terminal slope.
1
Linear/log trapezoidal method was used for AUC calculation.