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. Author manuscript; available in PMC: 2016 Mar 16.
Published in final edited form as: Exp Neurol. 2015 Sep 30;275(Pt 1):17–24. doi: 10.1016/j.expneurol.2015.09.016

Fig. 3.

Fig. 3

VMAT2 LO mice have increased sensitivity to the 5-HT2 agonist DOI. Wildtype and LO mice (4–6 months of age) were injected with saline or DOI (1 mg/kg) and placed in a cage for 10 min video-recorded observation of head twitches. When challenged with DOI, VMAT2 LO mice exhibited a 79% increase in the number of head twitches over wildtype mice (****p < 0.0001, n = 8–9 mice per group,).