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. 2016 Mar 16;3:16010. doi: 10.1038/mtm.2016.10

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Copyright © 2016 Official journal of the American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Transplanted cells maintain RPE cell marker expression, phagocytosed rhodopsin material, and decreased autofluorescence levels at 5 weeks PI. (a) Grafted cells are positive for CRALBP and mostly negative for Ki67. Rhodopsin-positive material is found within the cell membrane of HSM-labelled cells. (b) Autofluorescence in sham-injected eyes and in nongrafted areas was detected scattered all over the SRS, whereas in grafted areas it was limited to discrete spots of the RPE cell layer. Representative images of hiPSC-injected eyes are shown, but similar results were obtained in hESC-injected eyes. RPE, retinal pigment epithelium; SRS, subretinal space; ONL, outer nuclear layer; ONL, outer nuclear layer; INL, inner nuclear layer; GCL, ganglion cell layer.