Figure 3.

Overview of the original MDR algorithm as described in [2] on the left with categories of extensions or modifications on the right. The first stage is data input, and extensions to the original MDR method dealing with other phenotypes or data structures are presented in the section ‘Different phenotypes or data structures’. The second stage comprises CV and permutation loops, and approaches addressing this stage are given in section ‘Permutation and cross-validation strategies’. The following stages encompass the core algorithm (see Figure 4 for details), which classifies the multifactor combinations into risk groups, and the evaluation of this classification (see Figure 5 for details). Methods, extensions and approaches mainly addressing these stages are described in sections ‘Classification of cells into risk groups’ and ‘Evaluation of the classification result’, respectively.