Table 2.

Implementations of MDR-based methods

Method	Ref	Implementation	URL	Consist/Sig	Cov
MDR	[62, 63]	Java	www.epistasis.org/software.html	k-fold CV	Yes
	[64]	R	Available upon request, contact authors	k-fold CV, bootstrapping	No
	[65, 66]	Java	sourceforge.net/projects/mdr/files/mdrpt/	k-fold CV, permutation	No
	[67, 68]	R	cran.r-project.org/web/packages/MDR/index.html	k-fold CV, 3WS, permutation	No
	[69]	C++/CUDA	sourceforge.net/projects/mdr/files/mdrgpu/	k-fold CV, permutation	No
	[70]	C++	ritchielab.psu.edu/software/mdr-download	k-fold CV, permutation	No
GMDR	[12]	Java	www.medicine.virginia.edu/clinical/departments/psychiatry/sections/neurobiologicalstudies/genomics/gmdr-software-request	k-fold CV	Yes
PGMDR	[34]	Java	www.medicine.virginia.edu/clinical/departments/psychiatry/sections/neurobiologicalstudies/genomics/pgmdr-software-request	k-fold CV	Yes
SVM-GMDR	[35]	MATLAB	Available upon request, contact authors	k-fold CV, permutation	Yes
RMDR	[39]	Java	www.epistasis.org/software.html	k-fold CV, permutation	Yes
OR-MDR	[41]	R	Available upon request, contact authors	k-fold CV, bootstrapping	No
Opt-MDR	[42]	C++	home.ustc.edu.cn/∼zhanghan/ocp/ocp.html	GEVD	No
SDR	[46]	Python	sourceforge.net/projects/sdrproject/	k-fold CV, permutation	No
Surv-MDR	[47]	R	Available upon request, contact authors	k-fold CV, permutation	Yes
QMDR	[48]	Java	www.epistasis.org/software.html	k-fold CV, permutation	Yes
Ord-MDR	[49]	C++	Available upon request, contact authors	k-fold CV, permutation	No
MDR-PDT	[50]	C++	ritchielab.psu.edu/software/mdr-download	k-fold CV, permutation	No
MB-MDR	[55, 71, 72]	C++	www.statgen.ulg.ac.be/software.html	Permutation	No
	[73]	R	cran.r-project.org/web/packages/mbmdr/index.html	Permutation	Yes
	[74]	R	www.statgen.ulg.ac.be/software.html	Permutation	Yes

Ref = Reference, Cov = Covariate adjustment possible, Consist/Sig = Strategies used to determine the consistency or significance of model.