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Interactions between microRNAs (miRNAs) and pluripotency regulatory factors (a) in the embryonic stem cell (ESC) maintenance state and (b) upon induction of differentiation. The ESC-specific cell cycle (ESCC) miRNAs and Oct4/Nanog/Sox2 confer ESC maintenance. In contrast, let-7 supports the differentiated somatic cell state. Green lines indicate activation, red lines indicate repression, and gray lines indicate interactions that are not present in the indicated cell state.
