Table 1.
microRNA profile of pluripotent stem cells
| Percent of total microRNA profile | Conservation | Other tissues | |||||
|---|---|---|---|---|---|---|---|
| Human embryonic stem cell | Mouse embryonic stem cell | Mouse epiblast stem cell | |||||
| Min. | Max. | Min. | Max. | Single study | |||
| Clusters with ESCC microRNAs | |||||||
| miR-371-373 | 0.00 | 0.67 | – | – | – | hsa, mml | Germ cell tumor |
| miR-290-295 | – | – | 14 | 63 | 4 | mmu, rno | Placenta, germ cell tumor |
| miR-302-367 | 15.00 | 31.00 | 0.1 | 0.9 | 23.5 | hsa, mml, mmu, xtr | Germ cell tumor |
| miR-17-92b | 5.00 | 13.00 | 6 | 17.5 | 2.7 | hsa, mml, mmu, rno, xtr, dre | Germ cell tumor, lymphoma |
| miR-106a-363 | 0.50 | 1.50 | 2.3 | 4.8 | 2.9 | hsa, mml, mmu, rno, xtr, dre | Germ cell tumor, lymphoma |
| miR-106b-25 | 0.25 | 6.00 | 1.9 | 3.1 | 1.8 | hsa, mml, mmu, rno, xtr, dre | Germ cell tumor, lymphoma |
| Other microRNA clusters highly expressed in pluripotent cells | |||||||
| miR-200b-429 | 0.05 | 0.08 | 0.5 | 1.5 | 0.6 | hsa, mml, mmu, rno, xtr, dre | Adult tissue |
| miR-200c-141 | 0.20 | 0.40 | 0.2 | 1 | 0 | hsa, mml, mmu, rno, xtr, dre | Placenta, adult tissue |
| miR-183-182 | 0.01 | 0.09 | 1.5 | 20.5 | 14.8 | hsa, mml, mmu, rno, xtr, dre | Adult tissue, germ cell tumor, B-cell lymphoma |
| Ubiquitous and somatic microRNAs | |||||||
| miR-21 | 8.50 | 22.00 | 1.4 | 12.4 | 5.6 | hsa, mml, mmu, rno, dre | Ubiquitous |
| Combined ESCC microRNAs | |||||||
| 16.00 | 36.00 | 19 | 44 | 32 | |||
| Citations | |||||||
| Morin et al. 2008 | Bar et al. 2008 | Jouneau et al. 2012 | Marson et al. 2008 | Jouneau et al. 2012 | Kiezun et al. 2012 | Landgraf et al. 2007 | |
Abbreviations: dre, Danio rerio; ESCC, embryonic stem cell–specific cell cycle–regulating; hsa, Homo sapiens; mml, Macaca mulatta; mmu, Mus musculus; rno, Rattus norvegicus; xtr, Xenopus tropicalis.