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. Author manuscript; available in PMC: 2016 Mar 16.
Published in final edited form as: Annu Rev Cell Dev Biol. 2013 Jul 12;29:213–239. doi: 10.1146/annurev-cellbio-101512-122343

Table 2.

microRNAs that regulate reprogramminga,b

Category microRNA Species Seed region Fold change Factors Verified functional targets Citations
ESCC microRNA enhancers miR-372 hsa -aaagugcugc- 4–12× osk, oskm SMARCC2, MDB2, RBL2, CDC2L6, RHOC, MECP2, TGFBR2 Subramanyam et al. (2011)
miR-302 hsa -uaagugcuuc- 4–12× osk, oksm SMARCC2, MDB2, RBL2, CDC2L6, RHOC, MECP2, TGFBR2, P21, P130, NR2C2, AOF1, AOF2, MECP1-p66, MECP2 Subramanyam et al. (2011), Banito et al. (2009), Hu et al. (2012), Li et al. (2011), Lin et al. (2011)
mmu -uaagugcuuc- 10× osk Tgfbr2 Judson et al. (2009), Liao et al. (2011)
miR-294 mmu -aaagugcuuc- 8–70× osk Judson et al. (2009)
miR-295 mmu -aaagugcuac- 5× osk Judson et al. (2009)
miR-291-3p mmu -aaagugcuuc- 5× osk Judson et al. (2009)
ESCC-like microRNA enhancers miR-93 mmu caaagugcugu- 2–5× osk, oskm Tgfbr2, p21 Li et al. (2011), Pfaff et al. (2011)
miR-106a/b mmu caaagugcuaa- 2–5× osk, oskm Tgfbr2, p21 Li et al. (2011), Liao et al. (2011), Pfaff et al. (2011)
miR-17 mmu caaagugcuua- 3–4× oskm Tgfbr2, p21 Liao et al. (2011), Pfaff et al. (2011)
miR-20 mmu uaaagugcuua- 1.5–5× osk Liao et al. (2011), Pfaff et al. (2011)
ESCC-variant microRNA enhancers miR-130 mmu -cagugcaaug- 2–5× osk Meox2 Pfaff et al. (2011)
miR-301 mmu -cagugcaaua- 2–4× osk Meox2 Pfaff et al. (2011)
miR-721 mmu -cagugcaauu- 2–5× osk Meox2 Pfaff et al. (2011)
miR-148 mmu -ucagugcacua- 4× osk Pfaff et al. (2011)
Non-ESCC microRNA enhancers miR-138 mmu agcugguguug- 2.5× oskm p53 Ye et al. (2012)
miR-29b mmu uagcaccauuu- 2× oskm, osk Dnmt3a, Dnmt3b Guo et al. (2013)
microRNA inhibitors Let-7 mmu ugagguaguag- 0.25×, 0.5× osk, oskm n-Myc, Sall4, Lin28 Melton et al. (2010)
miR-21 mmu uagcuuaucag- 0.4×, 0.7× oskm, osk p85α, Spry1 Yang et al. (2011)
miR-29a mmu uagcaccaucu- 0.4× oskm Cdc42, p85α, Spry1 Yang et al. (2011)
miR-34a/b mmu uggcagugucu- 0.2–0.3× osk, oskm Nanog, Sox2, n-Myc Choi et al. (2011)
miR-199a-3p mmu acaguagucug- 0.3× osk, oskm Wang et al. (2012)
a

Bold indicates embryonic stem cell–specific cell cycle–regulating (ESCC) microRNA seed sequence.

b

Abbreviations: hsa, Homo sapiens; mmu, Mus musculus; osk, Oct4, Sox2, and Klf4; oskm, Oct4, Sox2, Klf4, and c-Myc.

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