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. Author manuscript; available in PMC: 2016 Mar 16.
Published in final edited form as: Transl Res. 2014 May 10;165(1):36–47. doi: 10.1016/j.trsl.2014.05.003

Figure 1. Functions of the Nucleosome Remodeling and Deacetylase (NuRD) Complex.

Figure 1

NuRD core components are shown in the illustration. NuRD regulates gene transcription through binding gene enhancers and promoters, and modifying the state of chromatin. More recent data implicate NuRD in DNA repair processes. Box on the right indicates known biochemical functions (top four on list) of NuRD components and biological roles of the complex. Increasingly, NuRD-independent functions are being described for some components (e.g., Mi2, Mta1). TF=tissue restricted transcription factors; DDR=DNA damage response

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