Skip to main content
. Author manuscript; available in PMC: 2016 Mar 16.
Published in final edited form as: Curr Top Membr. 2014;74:113–133. doi: 10.1016/B978-0-12-800181-3.00005-1

Figure 5.3.

Figure 5.3

A hypothetical cartoon model of how Ct affects TREK-1 activity. A cartoon model of a single TREK-1 subunit showing a hypothetical mechanism of channel activation by temperature. It was proposed that increasing temperature facilitates the transition of Ct from inactive to active conformation, leading to stabilization of an open conformation of the selectivity filter via interaction between Trp275 (W) and Gly137 (G) from a single TREK-1 subunit (Bagriantsev et al., 2012). M1–M4, transmembrane segment 1–4; P1–2, pore helix 1–2; Ct, C-terminal domain. Blue spheres depict potassium ions. (See the color plate.)