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. 2016 Feb 23;11(5):513–530. doi: 10.2217/nnm.16.3

Figure 4. . Paclitaxel-loaded magnetic nanoparticles applied to coronary stents with a uniform magnetic field.

Figure 4. 

MNPs with PTX doses of 7.5 and 0.75 μg entered into animal bodies under magnetic versus nonmagnetic conditions. The animals sacrificed and the stented carotid segments were harvested 14 days after surgery. The control group did not receive MNP but stented. Verhoeff–van Gieson-stained section of an artery lumen treated with 7.5 μg PTX under magnetic conditions (A) demonstrated versus ‘no treatment’ control (B) (p < 0.05, Dunn's Test Q statistic = 3.7). Original magnification 100×. Morphometric results as neointima/media ratios (C) pictured as a function of the magnetic field application and PTX dose (n ≥ 6). Data are presented as mean ± standard error.

MNP: Magnetic nanoparticle; NP: Nanoparticle; PTX: Paclitaxel.

Reprinted with permission from [57], © (2010) Proceedings of the National Academy of Sciences of the United States of America.