Figure 3.

Example of an ensemble of four oscillatory phenotypes in a two-dimensional slice of system design space for the D.12 design. (a,b) System design space with the effective rate constant for inactivation of the two regulators on the x and y axes, normalized with respect to the growth rate, μ, with a 1 h doubling time. See caption of Figure 2 for details. (c–f) Temporal behavior of normalized repressor concentration x₄ determined by simulation of the full system within the phenotypic regions of potentially oscillation in panels (a,b) indicated by the symbols in the upper-left corners (regions 43 ●, 16 ■, 45 ▲ and 18 ▼). It should be noted that sustained oscillations may dynamically cycle through different qualitatively distinct phenotypes in state space.¹¹