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Key: Responder: ≥30% reduction in “average pain for the past 24 hours” according to the NPRS score. Non-responder: <30% reduction in “average pain for the past 24 hours” according to the NPRS score. Tolerable AE: persistent AE typically including dizziness, nausea and somnolence, which do not result in treatment discontinuation. Intolerable AE; AE that result in treatment discontinuation. Abbreviations: AE, adverse event; NPRS, Numeric Pain Rating Scale.
