Skip to main content
. 2016 Mar 16;11(3):e0149685. doi: 10.1371/journal.pone.0149685

Table 1. Primary characteristics of the 35 included studies.

  All studies, n = 35
Designa
    Placebo-controlled, n (%) 16 (46)
    Active-controlled, n (%) 11 (31)
    Different doses, n (%) 14 (40)
    Not randomized, n (%) 10 (29)
Number of arms
    1, n (%) 7 (20)
    2, n (%) 14 (40)
    3, n (%) 14 (40)
Type
    Phase 2, n (%) 3 (9)
    Phase 3, n (%) 17 (49)
    Others, n (%) 15 (43)
Technique
    BPF, n (%) 9 (26)
    SIENA, n (%) 17 (49)
    Other, n (%) 9 (26)

aOne study could be in two designs.

BPF: Brain Parenchymal Fraction; SIENA: Structural Image Evaluation, using Normalisation, of Atrophy.