Fig 7. Liver histology of control and ²¹³Bi-BSA injected mice.

(A) Control liver, 26 weeks post-injection, (B) livers of mice 26 weeks after injection of 3.7 MBq ²¹³Bi-BSA, and (C, D, E, F) livers of mice 26 weeks after injection of 11.1 MBq ²¹³Bi-BSA. Livers of mice injected with 3.7 MBq ²¹³Bi-BSA do not show any significant histological injury. Livers of mice injected with 11.1 MBq ²¹³Bi-BSA show extramedullary haematopoiesis (C, arrow), isolated necrosis (D, arrow), karyomegaly (Ka), cytomegaly (Cy) and intranuclear acidophilic cytoplasmic invagination (INCI) (E). Inflammation and fibrosis are rarely observed (F, arrow). Haematoxylin-Eosin-Saffron (bar = 100 μm).