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. 2016 Mar 16;11(3):e0151330. doi: 10.1371/journal.pone.0151330

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© 2016 Dorso et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 9 — Comparison between kidneys of (A, D, G) control animals, (B, E, H) kidneys of mice 35 weeks after injection of 3.7 MBq of ²¹³Bi-BSA, (C and I) 26 weeks after injection of 11.1 MBq of ²¹³Bi-BSA and (F) 35 weeks after injection of 7.4 MBq of ²¹³Bi-BSA. Control kidneys, Haematoxylin-Eosin-Saffron (A), Periodic Acid Schiff (D), and Masson’s Trichrome (G). Kidneys of mice injected with 3.7 MBq ²¹³Bi-BSA do not show any significant histological injury (B (HES), E (PAS) and H (MT)). Kidneys of mice injected with 11.1 or 7.4 MBq ²¹³Bi-BSA show basophilic tubules, karyomegaly and cytomegaly (C, arrow) (HES), proteinaceous casts (F, arrow), (PAS), and glomerulosclerosis (I, arrow) (MT) (bar = 100 μm).