Table 2. Low-dose oral T3 treatment did not adversely affect heart rate and improved contractility.
Sham | MI | MI+T3 | |
---|---|---|---|
Heart rate (bpm) | 331±14 | 324±11 | 334±8 |
Rate-pressure product (mmHg/min) | 39420±2217 | 35157±1552 | 36026±1545 |
LV dP/dt(max) (mmHg/sec) | 8324±478 | 6892±228* | 7737±285# |
LV dP/dt(min) (mmHg/sec) | 8284±656 | 5119±384*** | 4967±417*** |
LVESP (mmHg) | 117±2 | 102±5* | 99±5* |
LVEDP (mmHg) | 6±0.5 | 10.6±1.6** | 11.9±0.8** |
Tau (msec) | 9.2±0.5 | 13.3±1.3* | 13.4±1.2* |
Arterial BP (mmHg) | 100±2 | 93±3 | 96±3 |
LV–Left ventricular; dP/dt(max)–maximal rate of LV pressure development
dP/dt(min)–maximal rate of LV pressure decline
ESP–End-systolic pressure
EDP–End-diastolic pressure
BP–Blood pressure
T3–triiodo-L-thyronine
MI–Myocardial Infarction
n = 7–8 sham; 7–9 MI-Veh; 11 MI+T3
*p<0.05
**p<0.01
***p<0.001 vs. Sham
#p<0.05 vs. MI.