Table 1.

Cytokine Gene Expression (calculated as percent of control) and Blood Ethanol Concentration (mg/dL) Following Intragastric Intubation of 4-g/kg Ethanol. Adult male rats were administered an intragastric 4-g/kg ethanol challenge, and tissue and trunk blood collected 3, 10, or 14 hr after intubation. Additionally, a control vehicle (VEH) group was given tap water, with these animals counterbalanced across time post-challenge. Expression of interleukin (IL)-1, IL-6, and tumor necrosis factor alpha (TNFα) mRNA in the paraventricular nucleus of the hypothalamus (PVN) was assessed (expressed as percent of control), as well as blood ethanol concentration (BEC; mg/dL) at the time of sacrifice. Values represent the mean, with standard error of the mean listed in parentheses. Bolded numbers represent a significant elevation relative to vehicle-treated rats.

	VEH	3 HR	10 HR	14 HR
PVN IL-1	108.2 (9.2)	102.1 (36.3)	111.0 (8.5)	93.9 (11.3)
PVN IL-6	107.0 (11.5)	217.2 (62.3)	73.8 (10.2)	76.3 (10.0)
PVN TNFα	112.4 (14.7)	123.9 (45.1)	129.1 (29.8)	144.1 (15.3)
BEC	16.53 (2.05)	175.12 (20.76)	35.22 (14.04)	20.18 (3.44)