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. Author manuscript; available in PMC: 2017 Jan 14.

Published in final edited form as: Mol Biochem Parasitol. 2016 Jan 14;204(2):64–76. doi: 10.1016/j.molbiopara.2015.12.004

Table 3.

Inhibitor Binding Affinities.^a,^b

	K_i versus substrate (μM)
			TcGlcK
Inhibitor	TcGlcK	HsHxKIV	selectivity ratio^c
BENZ-GlcN	32 ± 26	376 ± 196	12
CBZ-GlcN	0.71 ± 0.05	174 ± 50	245
HPOP-GlcN	1.3 ± 0.6	242 ± 97	186
DBT-GlcN	4.1 ± 0.3	nd^d	nd^d

^a

All compounds were tested as their racemic mixtures (n ≥ 2).

^b

Colorimetric assay; measurements in triplicate.

^c

Selectivity ratio = K_i (HsHxKIV) / K_i (TcGlcK).

^d

Not determined.