Table 3.

Three-way interaction among HPS haplotype, stress, and sex; two-way interactions between HPS haplotype and stress, HPS haplotype and sex, and sex and stress; and main effects of HPS haplotype, stress, and sex on different measures of experimental thermal pain sensitivity in the OPPERA cohort.

	HPS*Stress*Sex		HPS*Stress		HPS*Sex		Sex*Stress		HPS		Stress		Sex
	Coef	P	Coef	P	Coef	P	Coef	P	Coef	P	Coef	P	Coef	P
First Pulse (46)	−0.002	0.5366	−0.002	0.4339	0.038	0.6562	0.003	0.2522	0.058	0.3628	0.013	<0.0001	0.288	<0.0001
First Pulse (48)	−0.002	0.5735	−0.003	0.2862	0.048	0.5778	0.002	0.4730	0.086	0.1895	0.014	<0.0001	0.310	<0.0001
First Pulse (50)	0.000	0.9314	−0.003	0.1217	−0.023	0.7856	0.001	0.8268	0.124	0.0617	0.015	<0.0001	0.374	<0.0001
AUC (46)	0.001	0.6706	−0.005	0.0269	−0.014	0.8620	−0.002	0.4645	0.128	0.0472	0.017	<0.0001	0.426	<0.0001
AUC (48)	−0.001	0.7471	−0.005	0.0125	0.044	0.5775	−0.002	0.2498	0.126	0.0521	0.018	<0.0001	0.448	<0.0001
AUC (50)	0.001	0.6174	−0.007	0.0015	0.026	0.7533	−0.005	0.0163	0.148	0.0291	0.019	<0.0001	0.467	<0.0001
Maximum Pain (46)	0.002	0.5828	−0.006	0.0059	−0.027	0.7509	−0.003	0.1912	0.160	0.0176	0.018	<0.0001	0.445	<0.0001
Maximum Pain (48)	−0.001	0.7727	−0.006	0.0018	0.027	0.7412	−0.003	0.1143	0.161	0.0184	0.019	<0.0001	0.452	<0.0001
Maximum Pain (50)	0.001	0.7809	−0.007	0.0007	0.033	0.6984	−0.006	0.0034	0.144	0.0460	0.019	<0.0001	0.463	<0.0001

AUC = area under the curve; (46), (48), and (50) indicate the temperature used in degrees Celsius; Coef = coefficient; P = p-value. Significant p-values (<0.05) are bolded.