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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Radiother Oncol. 2016 Jan 28;118(2):315–322. doi: 10.1016/j.radonc.2016.01.011

Figure 4.

Figure 4

Continuous (non-linear) dose-response characterization of late T1 superior pharyngeal constrictor SI alteration from the baseline. 4a) Confirmatory analysis of the RPA-derived T1 SI change threshold; ROC shows split performance for T1 SI changes of > or <0.57 in the superior pharyngeal constrictors, as a function of Dmean, with an AUC of 0.72 (P=0.013, with H0 denoting AUC =0.5). 4b) Sigmoidal fit of the observed probability of threshold T1 SI alteration as function of Dmean to superior pharyngeal constrictor muscles (R2=0.93). 4c) Incidence-resampled bootstrap predicted the probability of threshold T1 alteration as a function of dose; 104 independently resampled distributions were individually fit using a maximum likelihood 2P-sigmoidal function, representing the range of possible dose-response normal tissue complication probability curves to best approximate a “true population incidence.”