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Summary of enhancement of RG7787 activity by combination with DDR1 siRNA or with DDR1 Inhibitor 7rh in MSLN-expressing cell lines
| Cell line | Control si + RG7787 IC50 (ng/ml) | DDR1 siRNA + RG7787 IC50 (ng/ml) | RG7787 alone IC50 (ng/ml) | 7rh + RG7787 IC50 (ng/ml) |
|---|---|---|---|---|
| KB | 40 | 2 | >100 | 6 |
| A431/H9 | 11 | 1.5 | 2 | 0.1 |
| HAY | 11 | 1.5 | 35 | 5 |
| KLM1 | 8 | 3.7 | 11 | 2 |
| ASPC1 | 40 | 0.7 | -- | -- |
| L55S | -- | -- | 10 | 3 |
| SUM149 | -- | -- | 11 | 1 |
| HCC70 | -- | -- | 4 | 0.4 |
