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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Mol Cancer Res. 2015 Dec 18;14(3):241–252. doi: 10.1158/1541-7786.MCR-15-0360

Figure 2.

Figure 2

Down-regulation of cyclin A2 by aspirin and salicylic acid is mediated by 26S proteasomal pathway. A, effect of lactacystin on the ability of aspirin and salicylic acid to decrease cyclin A2 protein levels in HT-29 cells. B, represents the quantification of the bands in blot A. C and D, aspirin and salicylic acid down-regulate exogenously expressed DDK-tagged cyclin A2 protein. C and D, respectively represent immunoblots probed with anti-DDK tagged antibody and anti-cyclin A2 antibody. Positions of the exogenous and endogenous cyclin A2 were shown by arrows (see the text for details).