Table 4.

A: Surrounding Non-Tumor Tissue Markers by Disease Type
		IBC Matched Non-Tumor Tissue (N=45)	Treated IDC Matched Non-Tumor Tissue (N=24)	Untreated IDC Matched Non-Tumor Tissue (N=27)	P-Value
pS6	0	7 (21.9%)	0	0	<0.0001^
	1+	22 (68.8%)	19 (82.6%)	2 (7.4%)
	2+	3 (9.4%)	4 (17.4%)	25 (92.6%)
	3+	0	0	0
	No normal tissue	11	1
	Analysis N/A	2
pJAK2	0	20 (60.6%)	1 (4.2%)	10 (52.6%)	<0.0001^
	1+	10 (30.3%)	9 (37.5%)	9 (47.4%)
	2+	2 (6.1%)	14 (58.3%)	0
	3+	1 (3.0%)		0
	No normal tissue	9		8
	Analysis N/A	3
pSTAT3	0	20 (66.7%)	10 (45.5%)	2 (4.3%)	<0.0001^
	1+	4 (13.3%)	11 (50%)	12 (85.7%)
	2+	6 (20.0%)	1 (4.6%)	0
	No normal tissue	10	2	12
	Analysis N/A	5		1
IL6	0	16 (50%)	6 (25%)	1 (6.3%)	0.0069^
	1+	14 (43.8%)	16 (66.7%)	15 (93.8%)
	2+	2 (6.3%)	2 (8.3%)	0
	No normal tissue	10		10
	Analysis N/A	3		1
CD68*	Median (range)	15 (0–150)	15 (5–60)	20 (7–40)	0.0739^^
	No Tumor Available
	No Tissue Available	5
CD163*	Median (range)	12 (2–40)	15.5 (5–40)	15 (4–35)	0.1487^^
	No Tumor Available
	No Tissue Available	4

B: Pairwise Comparisons of Expression Levels in Surrounding non-Tumor Tissue – P-Values (Pairwise Comparisons of Table 4A)
	IBC vs Treated IDC	IBC vs Untreated IDC	Treated IDC vs Untreated IDC
pS6^	0.0408	<0.0001	<0.0001
pJAK2^	<0.0001	0.5383	<0.0001
pSTAT3^	<0.0001	<0.0001	0.0007
IL6^	0.1580	0.0018	0.1753
CD68^^	0.1554	0.0294	0.5225
CD163^^	0.0729	0.1651	0.7318

^{^}Fisher's Exact Test

^{^^}Kruskal-Wallis non parametric analysis of variance test

^*p<0.0167 is considered significant

^{^}Fisher’s Exact Test

^{^^}Wilcoxon Rank Sum Test