Table 1.
Change in radiographic joint space width (JSW) and in medial femorotibial compartment (MFCT) and central tibia (cMT) cartilage thickness over a period of two years (T-2 →T0) in knees from **BLINDED** prior to knee replacement (KR; n=119) and in non-KR control knees (n=119) matched 1:1 by Kellgren-Lawrence grade (KLG), sex, and age. Values in μm.
| KR Cases Mean ± SD |
Controls Mean ± SD |
Paired T P-value |
Cc P-value |
ccOR [95% CI] |
ccbp P-value |
ccbp_OR [95% CI] |
|
|---|---|---|---|---|---|---|---|
| mJSW | -415±1008 | -133±621 | 0.0058 | 0.0039 | 1.38 [1.11,1.71] | 0.0015 | 1.45 [1.15,1.83] |
| JSW 22.5% | -610±1059 | -162±650 | 0.0001 | 0.0003 | 1.57 [1.23,2.01] | 0.0003 | 1.64 [1.26,2.15] |
| MFTC | -223±372 | -95±189 | 0.001 | 0.0003 | 1.38 [1.16,1.64] | 0.0002 | 1.4 [1.17,1.66] |
| cMT | -178±249 | -57±155 | <.0001 | <.0001 | 1.57 [1.27,1.95] | <.0001 | 1.6 [1.29,1.99] |
|
| |||||||
| OV1 | -513±490 | -289±174 | <.0001 | <.0001 | 1.53 [1.25,1.87] | <.0001 | 1.56 [1.26,1.92] |
| OV2 | -368±376 | -194±124 | <.0001 | <.0001 | 1.57 [1.3,1.9] | <.0001 | 1.61 [1.32,1.96] |
| OV3 | -291±349 | -150±109 | <.0001 | <.0001 | 1.51 [1.24,1.82] | <.0001 | 1.53 [1.26,1.87] |
| OV4 | -234±279 | -111±78 | <.0001 | <.0001 | 1.5 [1.24,1.8] | <.0001 | 1.52 [1.25,1.84] |
| OV5 | -184±233 | -88±73 | <.0001 | <.0001 | 1.47 [1.23,1.75] | <.0001 | 1.49 [1.24,1.79] |
| OV6 | -145±191 | -68±69 | 0.0001 | <.0001 | 1.48 [1.24,1.75] | <.0001 | 1.5 [1.26,1.78] |
| OV7 | -100±154 | -49±62 | 0.0016 | 0.0003 | 1.43 [1.18,1.74] | 0.0002 | 1.44 [1.19,1.75] |
| OV8 | -72±108 | -34±60 | 0.0016 | 0.0003 | 1.4 [1.17,1.67] | 0.0002 | 1.4 [1.18,1.68] |
| OV9 | -46±80 | -21±59 | 0.0088 | 0.0036 | 1.35 [1.1,1.65] | 0.0029 | 1.35 [1.11,1.66] |
| OV10 | -27±77 | -6±59 | 0.0212 | 0.0093 | 1.3 [1.07,1.59] | 0.0071 | 1.32 [1.08,1.61] |
| OV11 | -1±67 | 10±58 | 0.1559 | 0.1052 | 1.19 [0.96,1.48] | 0.0927 | 1.2 [0.97,1.5] |
| OV12 | 23±62 | 28±57 | 0.5074 | 0.4781 | 1.09 [0.86,1.38] | 0.4551 | 1.1 [0.86,1.4] |
| OV13 | 46±62 | 41±58 | 0.5648 | 0.5645 | 0.93 [0.72,1.2] | 0.5797 | 0.93 [0.72,1.2] |
| OV14 | 75±67 | 60±62 | 0.0715 | 0.0855 | 0.8 [0.61,1.03] | 0.0705 | 0.79 [0.62,1.02] |
| OV15 | 110±78 | 95±74 | 0.1317 | 0.1474 | 0.82 [0.63,1.07] | 0.0988 | 0.81 [0.63,1.04] |
| OV16 | 184±103 | 154±91 | 0.022 | 0.0153 | 0.76 [0.61,0.95] | 0.0092 | 0.75 [0.6,0.93] |
|
| |||||||
| Thinn. Score | -2066±2277 | -1111±766 | <.0001 | <.0001 | 1.48 [1.24,1.75] | <.0001 | 1.51 [1.27,1.8] |
| Thick.Score Change Score | 524±377 2590±2182 | 489±402 1600±610 | 0.4846 <.0001 | 0.4724 <.0001 | 0.91 [0.7,1.18] 0.65 [0.54,0.79] | 0.4537 <.0001 | 0.9 [0.69,1.18] 0.63 [0.52,0.77] |
SD standard deviation; CI = confidence interval; ccOR = case-control conditional logistic regression odds ratios adjusting for matching variables and bilateral knees; ccORbp = ccOR adjusting for the above and additionally for the effects of BMI and pain at baseline (T-2); mJSW = minimum joint space width in the medial femorotibial compartment, measured using fixed flexion radiographs; JSW225 = joint space width measured at a fixed location(22.5% from medial to lateral) in the medial femorotibial compartment, measured using fixed flexion radiographs; MFTC = total medial femorotibial compartment cartilage loss, as measured quantitative by MRI; cMT = central medial tibial cartilage loss, as measured quantitative by MRI; OV = ordered values = cartilage loss throughout 16 femorotibial subregions, sorted individually by magnitude (i.e. 1-16); Thinn. Score = total subregional thinning score = sum of all negative cartilage thickness changes across as many of the 16 subregions in which cartilage loss occurred in each knee, Thick. Score = total subregional cartilage thickening score = the sum of all positive cartilage thickness changes; Change Score = total subregional cartilage change score = sum or all 16 subregional cartilage thickness changes, independent of direction