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. Author manuscript; available in PMC: 2017 Mar 15.
Published in final edited form as: Cancer Res. 2016 Feb 1;76(6):1538–1548. doi: 10.1158/0008-5472.CAN-15-1804

Figure 7. Activation of MYC-dependent gene expression in KRAS mutant lung adenocarcinomas.

Figure 7

A. Heatmap of 82 MYC-dependent genes in 58 lung adenocarcinomas (GSE32867) demonstrating increased gene expression in KRAS mutant tumors (n=22) (denoted by black hash marks below heatmap) as compared to KRAS wild-type tumors (n=36). Samples displaying overexpression of MYC target genes are enclosed within a thick black rectangle. B. Relative MYC gene expression in KRAS wild-type (WT) and mutant (MUT) tumors. C. Relative MYC gene expression in EGFR wild-type and mutant tumors. Graphs display mean±SEM of MYC gene expression normalized to the median value of wild-type tumors. D. Heatmap of 82 MYC-dependent genes in 38 lung adenocarcinomas (GSE29066) demonstrating increased gene expression in KRAS mutant tumors (n=12) as compared to KRAS wild-type tumors (n=26). Pearson correlation analysis of MUC1 and MYC gene expression in KRAS mutant (E) and wild-type (F) tumors.