Figure 8. Effect of a prolyl hydroxylase (PHD) inhibitor on H₂O₂-evoked nocifensive behaviours.

Mice were injected i.pl. with the PHD inhibitor dimethyloxalylglycine (DMOG; 25 μg/paw) or saline. One hour after the pretreatment, mice were injected with H₂O₂ (1.5%, 20 μL/paw) or saline. The time mice spent in H₂O₂-evoked nocifensive behaviours, such as ipsilateral paw licking and flicking, was measured for 5 min. The TRPA1 antagonist HC-030031 (100 mg/kg) or vehicle was administered i.p. 30 min before the H₂O₂ injection. n = 5–8, ***P < 0.001.