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A subset of E1E2 clones transferred to a chimeric HCVcc infection model has neutralization sensitivity concordant with that in the HCVpp model. (Left) Two E1E2 clones showing high resistance in the HCVpp panel were transferred into the J6/JFH-1 backbone and neutralized, along with J6, JFH-1, and H77, with increasing concentrations of MAb 1:7. The error bars indicate SD. (Right) The IC50s for both the HCVcc and HCVpp showed significant correlation (r = 0.8938; P = 0.0152).
