TABLE 3.
Degree of shift in sensitivity of Env-pseudotyped viruses to G37080 BCN plasma depleted with monomeric and trimeric Envs and C1C peptide
| Env-pseudotyped virus | Fold reduction in neutralization (ID50)a |
||
|---|---|---|---|
| gp140 trimer (BG505-SOSIP.664) | gp120 monomer (4-2.J41) | MPER (C1C peptide) | |
| 25710-2.3 | >10.30 | 1.3 | 0.83 |
| 25711-2.4 | >8.52 | 1.4 | 1.44 |
| 3-5.J25 | >7.85 | 0.9 | 0.84 |
| 4-2.J41 | 12.11 | 1.1 | 1.04 |
| IAVI_C22 | >15.92 | 1.2 | 1.18 |
| 92BR020 | >35.08 | 1.1 | 1.34 |
| 93IN905 | 3.41 | 1.2 | 0.94 |
| JRCSF | >8.75 | 0.5 | 0.93 |
| Q23.17 | >23.28 | 1.0 | 0.98 |
| Du156.12 | >15.73 | 0.8 | 1.61 |
| HVTR-PG80v1.eJ7 | >10.03 | 0.9 | 1.12 |
| HVTR-PG80v1.eJ19 | >15.60 | 0.5 | 1.18 |
| HIV-2 7312A-C1C | >10 | ||
a
Fold reduction in virus neutralization was obtained by comparing the neutralization titer (ID50 values) of panel viruses against undepleted and depleted G37080 plasma. ID50 values are reciprocal dilutions at which the undepleted and depleted plasma conferred 50% neutralization of the Env-pseudotyped viruses in TZM-bl cells.