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Dose-response relationship for the incubation period and probability of infection of tg338 mice inoculated (20 μl, intracerebral route) with 10% (wt/vol) homogenate, prepared using posterior brainstem from two VRQ/VRQ sheep inoculated with the PG127 scrapie isolate and at the terminal stage of disease. The model values are represented by the solid line, and observed are values given as crosses. ic, intracranial; LD50, 50% lethal dose.
