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. 2016 Mar 17;6:23317. doi: 10.1038/srep23317

Figure 1. Fasting signal induces PPARα activation and ketogenesis.

Figure 1

(A–C) Effect of fasting on hepatic Aox-PPRE-luciferase reporter activity (A), serum total ketone body (B) as well as mRNA amounts for hepatic ketogenic genes (C) in mouse liver. Quantification of luminescent intensity of (A) was shown. (D) Aox-PPRE-luciferase reporter activity in primary hepatocytes infected with Ad-PPARα or not. Effect of FSK, WY14643 or both was shown. E, Effect of FSK, WY14643 or both on mRNA amounts of ketogenic genes in HepG2 cells.