Table 1.
Consensus aryl hydrocarbon receptor response elements (AHREs) in human stem cell- and migration/invasion-associated gene promoters
| Gene | # of Consensus AHREs and location relative to TSS | |
|---|---|---|
| Standard | Cyp1b1 | 8 (−206, −267, −840, −859, −944, −1028, −1678, −2392) |
| Stem cell markers | Aldh1a1 | 0 |
| Sox2 | 7 (−617, −749, −1284, −1430, −1678, −2577, +59) | |
| Nanog | 9 (−83, −140, −169, −430, −683, −1076, −2019, −2103, +146) | |
| Dppa3 | NA | |
| Pou5f1 | 3 (−1403, −2203, −2289) | |
| Bmi1 | 5 (−64, 328, −369, −2275, −2428) | |
| Notch1 | 13 (−75, −284, −367, −655, −743, −982,-1270, −1838, −1844, −2114, −2140, +52, +196) | |
| Notch2 | NA | |
| Msi1 | 7 (−270, −559, −904, −1821, −2114, −2686, +190) | |
| Invasion and migration markers | Snai1 | 5 (−82, −148, −1836, −1944, +216) |
| Twist1 | NA | |
| Vim | 6 (−360, 384, −927, −1003, +224, +294) | |
| Twist2 | 2 (−314, −2114) | |
| Tgfb1 | 5 (−836, −1936, −2037, −2190, −2734) | |
| Snai2 | 5 (−576, −2016, −2821, −2823, +50) | |
| Fn1 | 1 (−2023) |
Consensus AHREs were searched up to 3,000 bp upstream and 300 bp upstream of the transcription start site using Transcriptional Regulatory Element Database (http://rulai.cshl.edu)