Table 1.

Eight top hit compounds

Chemical structure	CHEMBLID	MMV number	Alternative compound number	Average Pf IVT	Specificity index	CHEMBL IC50 in uM	CHEMBL IC50 in human fibroblast (MRC-5) cells to measure toxicity
a	CHEMBL600904	MMV008270	GNF-Pf-780	0.27	1.96	1.93	>32000 nM
b	CHEMBL536393	MMV019124	TCMDC-123658	0.39	2.05	0.51	>32000 nM
c	CHEMBL532525	MMV665886	TCMDC-125438	0.62	1.69	0.77	>32000 nM
d	CHEMBL589060	MMV666057	TCMDC-125853	0.71	1.55	0.61	>32000 nM
e	CHEMBL546994	MMV666693	TCMDC-124577	0.71	1.57	0.06	>32000 nM
f	CHEMBL588732	MMV007564	GNF-Pf-4877;TCMDC-124400	0.72	1.51	0.53; 0.75	>32000 nM
g	CHEMBL1198651	MMV007764	GNF-Pf-4338	0.74	1.59	0.31	=19329.43 nM
h	CHEMBL530149	MMV006767	GNF-Pf-3828;TCMDC-123992	0.75	1.61	0.41; 1.13	>32000 nM

After filtering for several attributes, this study offers a final list of eight hit compounds. The chemical structure letter corresponds to the structures found in Fig. 3. Listed in this Table are the CHEMBL names, MMV number, any alternative compound name found in databases, the average normalized luciferase output, specificity index, the CHEMBL IC₅₀, and CHEMBL cytotoxicity IC₅₀ data from human fibroblast (MRC-5) cells