Fig. 1.
High membrane expression of SFK pathway members increases disease specific survival in a ccRCC patient cohort. a Representative pictures showing membrane, cytoplasmic and nuclear staining for SFK family members and downstream targets. (b–d) Kaplan Meier curves showing high membrane expression of (b) Fyn and (c) Hck and (d) Yes significantly increased disease specific survival by 2–3 years in a cohort of 192 ccRCC patients. e Kaplan Meier showing high levels of FAK phosphorylation at Y861 within the cellular membrane also increases disease specific survival by 2–3 years. Data shown is the average histoscore for 3 cores per patient and significance was set at 0.05