Table 1.
Agreement between cobas and H28 for HPV-DNA detection by type categories
| Results cobas/H28 | HPV distribution by type categories | ||
|---|---|---|---|
| N (%) | Any hrHPVa | HPV16/18b | Pool: 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68 |
| Pos/Pos | 112 | 20 | 97 |
| Pos/Neg | 16 | 5 | 15 |
| Neg/Pos | 24 | 5 | 22 |
| Neg/Neg | 245 | 367 | 263 |
| Total | 397 | 397 | 397 |
| Kappa (95 % CI) | 0.77 (0.71–0.84) | 0.79 (0.66–0.92) | 0.77 (0.71–0.84) |
| % Total Agreement | 89.9 | 97.5 | 90.7 |
| % Positive Agreementc | 84.8 | 80.0 | 84.0 |
| P value | <0.001 | <0.001 | <0.001 |
Abbreviations: H28 Seegene Anyplex™ II HPV28, Pos Positive, Neg Negative, N number
aAny high-risk HPV: HPV 16 and/or HPV18 and/or HPV 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68
bHPV16/18: HPV16 and or HPV18
cThe proportion of positive agreement between paired cobas and H28 samples was calculated using 2a/(f1 + g1), where a is the number of samples that were positive for HPV in both tests, f1 is the number of samples that were positive for cobas, and g1 is the number of samples that were positive for H28