Table 4.
Comparison of IVF data among moderate, severe/critical OHSS and non-OHSS patients
| Items | Non-OHSS group (n = 197) | Moderate OHSS (n = 39) | Severe/critical OHSS (n = 151) | P1 | P2 |
|---|---|---|---|---|---|
| Age (years) | 32.0 ± 3.8 | 32.0 ± 4.4 | 32.0 ± 4.0 | 0.929 | 0.875 |
| BMI (kg/m2) | 22.1 ± 2.8 | 22.0 ± 3.3 | 21.9 ± 2.9 | 0.643 | 0.490 |
| Nulligravida, n (%) | 112 (56.9) | 21 (53.8) | 86 (57.0) | 0.729 | 0.985 |
| Duration of infertility (years), median (IQR) | 4 (2–6) | 5 (3–8) | 4 (2–6) | 0.227 | 0.757 |
| Indication for IVF, n (%) | |||||
| Anovulation | 42 (21.3) | 8 (20.5) | 42 (27.8) | 0.910 | 0.161 |
| PCOS | 27 (13.7) | 8 (20.5) | 13 (8.6) | 0.274 | 0.140 |
| Tubal | 84 (42.6) | 14 (35.9) | 64 (42.4) | 0.435 | 0.962 |
| Male | 86 (43.7) | 22 (56.4) | 62 (41.1) | 0.144 | 0.627 |
| Endometriosis | 33 (16.8) | 5 (12.8) | 29 (19.2) | 0.542 | 0.553 |
| Unexplained | 3 (1.5) | 1 (2.6) | 2 (1.3) | 0.517 | 1.000 |
| Multiple | 54 (27.4) | 13 (33.3) | 49 (32.5) | 0.454 | 0.307 |
| Basal FSH (μU/ml) | 6.81 ± 2.18 | 6.32 ± 1.33 | 6.53 ± 2.01 | 0.171 | 0.256 |
| COH protocol, n (%) | 0.866 | 0.039 | |||
| Long protocol | 103 (52.3) | 21 (53.8) | 88 (58.3) | ||
| Short protocol | 37 (18.8) | 9 (23.1) | 12 (7.9) | ||
| Ultra-long protocol | 20 (10.2) | 3 (7.7) | 19 (12.6) | ||
| Step-down long protocol | 37 (18.8) | 6 (15.4) | 32 (21.2) | ||
| Gn dosage (U) | 2477 ± 830 | 2262 ± 834 | 2254 ± 760 | 0.120 | 0.007 |
| Serum E2 on HCG day (pg/ml) | 3513 ± 1560 | 4414 ± 3998 | 3670 ± 1686 | 0.084 | 0.356 |
| HCG dose on HCG day, n (%) | 0.008 | 0.816 | |||
| HCG 10,000 U | 134 (68.0) | 19 (48.7) | 99 (65.6) | ||
| HCG 5000 U | 8 (4.1) | 6 (15.4) | 8 (5.3) | ||
| rHCG | 55 (27.9) | 14 (35.9) | 44 (29.1) | ||
| Count of M-II oocytes, median (IQR) | 13 (10–16) | 13 (10–17) | 13 (10–16) | 0.469 | 0.956 |
| Embryos retrieved, median (IQR) | 12 (9–15) | 11 (10–17) | 12 (9–15) | 0.703 | 0.804 |
| Embryos transferred, median (IQR) | 2 (2–3) | 2 (2–3) | 2 (2–3) | 0.642 | 0.065 |
| Luteal supporting protocol, n (%) | 0.054 | 0.210 | |||
| Progesterone | 3 (1.6) | 3 (9.1) | 7 (4.7) | ||
| Progesterone with HCG | 176 (95.7) | 29 (87.9) | 137 (91.3) | ||
| Progesterone with rHCG | 5 (2.7) | 1 (3.0) | 6 (4.0) | ||
| HCG dose for luteal-sup (U) | 3443 ± 2201 | 2517 ± 1271 | 2306 ± 1825 | 0.071 | <0.001 |
Data were showed as mean ± SD, median (IQR), or n (%). P1 represents moderate OHSS compared with non-OHSS patients and P2 represents severe/critical OHSS compared with non-OHSS patients. OHSS: Ovarian hyperstimulation syndrome; BMI: Body mass index; IVF: In vitro fertilization; PCOS: Polycystic ovary syndrome; FSH: Follicle-stimulating hormone; COH: Controlled ovarian hyperstimulation; Gn: Gonadotropin; HCG: Human chorionic gonadotropin; rHCG: Recombinant human chorionic gonadotropin; M-II: Mature-II; IQR: Interquartile range; E2: Estradiol; SD: Standard deviation.