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. Author manuscript; available in PMC: 2016 Mar 17.
Published in final edited form as: Sci Transl Med. 2012 Feb 29;4(123):123ra24. doi: 10.1126/scitranslmed.3003500

Fig. 6.

Fig. 6

Effect of siRNA knockdown and c-Abl1 TK inhibition on Ebola virus replication. (A) Effect of a nontargeted siRNA control or individual siRNAs targeting c-Abl1 (S9, S10, and S11) on Zaire strain Ebola virus (EBOV) release from Vero cells on day 7 after infection. Cells were infected at a multiplicity of infection (MOI) of 1. Background viral load for day 1 was subtracted. Data are presented as means ± SEM of individual measures with cells from two independent experiments. (B) Viral load was measured in supernatant fluids of Vero cells infected with Zaire strain Ebola virus and treated with nilotinib (20 μM). Viral load was measured by TCID50 on days 0, 1, 2, 7, and 8 after infection compared to DMSO vehicle control. Background viral load for day 0 was subtracted. Data are presented as means ± SEM of four individual measures, and significance was analyzed by paired Student’s t test.