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. Author manuscript; available in PMC: 2016 Mar 17.
Published in final edited form as: Eur J Med Chem. 2015 Jan 10;92:693–699. doi: 10.1016/j.ejmech.2015.01.020

Fig. 5.

Fig. 5

Monoketone curcumin analogs inhibit the growth of Mycobacterium tuberculosis (Mtb). (A) Initial screening of inhibitory properties against Mtb analyzed by disk diffusion assays. 100 mM of curcumin analogs was added to Mtb strain H37Rv containing plate, incubated for 28 days at 37 °C, and zone of inhibition measured; (B) Liquid culture assay validating that UBS-109 inhibits H37Rv strain of Mtb. Different concentration of analogs were added to Mtb culture, incubated for 8d, then the OD600 was measured.; (C) Liquid culture assay validating that UBS-109 inhibits Beijing strain of Mtb; (D) Liquid culture assay validating that UBS-109 inhibits rifampicin-resistence strain of H37Rv Mtb; (E) Liquid culture assay validating that EF-24 inhibits H37Rv strain of Mtb; (F) Liquid culture assay validating that EF-24 inhibits Beijing strain of Mtb; (G) Liquid culture assay validating that EF-24 inhibits rifampicin-resistence strain of H37Rv Mtb.