Table 1.
Diffusion imaging studies of long-term forms of memory and their findings in regards to the uncinate fasciculus (UF). Only studies that used standard DTI measures (Fractional Anisotropy (FA), Mean Diffusivity (MD), Axial Diffusivity (AD), and Apparent Diffusion Coefficient (ADC) are included. Studies that examined populations with known white matter pathology (e.g. multiple sclerosis) were excluded. A ‘0’ in the right-most columns indicates that no significant correlation was observed. When a significant effect was observed, it is noted for the left uncinate (L UF), right uncinate (R UF), or combined (L+R). Abbreviations: Alz = Alzheimer's Disease; BNT = Boston Naming Task; CVLT = California Verbal Learning Task; MMSE = Mini-Mental State Examination; MCI = mild cognitive impairment; TL = temporal lobe; WAIS = Weschler Adult Intelligence Task; WMS = Weschler Memory Scale.
| Author | Control population (mean age) | Special population (M age) | Tasks | L UF | R UF | L + R |
|---|---|---|---|---|---|---|
| Correlations with Verbal Episodic Memory | ||||||
| Mabbott et al. (2009) | – | Children (M = 12) | CVLT | FA | 0 | – |
| Wendelken et al. (2014) | HC (M = 19) | Children (M = 10) | Selective Memory Encoding Task | FA | FA | – |
| McDonald et al. (2008) | HC (M = 39) | TL Epilepsy (M = 34) |
1. WMS - auditory immediate and delayed memory; 2. BNT | FA | 0 | – |
| Diehl et al. (2008) | HC | TL Epilepsy (M = 40) | WMS - auditory immediate and delayed memory | FA/ADC | 0 | – |
| Nestor et al. (2008) | HC (M = 41) | Schizophrenia (M = 39) | WMS - complete | 0 | 0 | – |
| Fujie et al. (2008) | HC (M = 71) | MCI (M = 72) | WMS – logical memory | FA | 0 | – |
| Lockhart et al. (2012) | HC (M = 24) |
Low or High White Matter Hyperintensity Adults (M=76; 77) | Common object-color source memory task - 2 hour delay | – | – | FA |
| Correlations with Visual Episodic Memory | ||||||
| Niogi et al. (2008) | HC (M = 30) |
Traumatic Brain Injury (M = 32) | 1.Attentional Network Test; 2. CVLT | 0 | FA | |
| Hanlon et al. (2012) | HC (M = 38) |
Schizophrenia (M = 33) |
Virtual Morris Water Maze | – | – | FA |
| McDonald et al. (2008) | HC (M = 39) | TL Epilepsy (M = 34) | WMS – visual, immediate and delayed memory | 0 | 0 | – |
|
Diehl et al. (2008) |
HC | TL Epilepsy (M = 40) | WMS - visual immediate and delayed memory | 0 | ADC | – |
| Sasson et al. (2010) | HC (M = 51) | – | 1. Benton Visual Retention Test; 2. Brief Visuospatial Memory Test; 3.Finger tapping task | AD, FA, AD, RD | 0 | – |
| Hirni et al. (2013) | Older HC (M=72) | MCI (M=73); Alz (M=67) | 1. CVLT (no effect); 2. Rey-Osterrieth; 3. BNT; 4. Category Verbal Fluency -Animals | – | – | FA |
| Metzler-Baddeley et al. (2011) | – | Older adults (M = 68) | 1. Object location; 2. Doors and People (no effect) | – |
– |
FA |
| Metzler-Baddeley et al. (2012) | Older HC (M = 74) | Mild Cognitive Impairment (M = 77) | 1.Doors and People; 2. Face recognition and confidence | AD, RD |
AD, RD |
– |
| Other measures of memory | ||||||
| Kiuchi et al. (2009) | Older HC (M = 72) | MCI (M = 73); Alz (M = 75) | 1. MMSE; 2. Alz Assessment Scale | ADC | FA, ADC | ADC |