Table 3. Genome-wide significant SNPs in the MESA Whites discovery set, Framingham Offspring replication set and combined P-values.

					Discovery				Replication
					MESA Whites				Framingham Offspring			Combined
SNP	CHR	POS AND ALLELE CHANGE	Type	Gene	SNP P-val	P-val	GC P-val	MAF	SNP P-val	P-val	MAF	P-val
rs4704963	5	g.158247378T>C	Intronic	EBF1	0.022	7.14E−09	1.99E−07	0.07	NA	NA	NA	NA
rs17056278	5	g.158252438C>G	Intronic	EBF1	0.022	7.14E−09	1.99E−07	0.07	0.308	0.007	0.07	2.98E−08
rs17056298	5	g.158268679C>G	Intronic	EBF1	0.018	1.30E−08	3.24E−07	0.06	0.230	0.012	0.07	7.92E−08
rs10077799	5	g.158272083T>C	Intronic	EBF1	0.016	1.71E−08	4.05E−07	0.06	NA	NA	NA	NA
rs17056318	5	g.158285953T>C	Intronic	EBF1	0.011	2.33E−08	5.18E−07	0.07	0.152	0.008	0.07	8.41E−08

Abbreviation: NA, not available/not applicable.

(Discovery) The table includes P-values for the SNP-only model (SNP P-val), that is, the additive genetic model with no interaction term, G × E P-values (P-val), genomic control G × E P-values (GC P-val), and MAF of the five SNPs with genome-wide significant P-values from the MESA Whites G × E GWAS on Hip Circumference (HIPCM). The environment (E) component in this GWAS was chronic psychosocial stress (STRESS). (Replication) The table includes P-values of SNP-only Model (SNP P-val), G × E P-values (P-val), and MAF of three out of the five SNPs available in Framingham Offspring Cohort. (Combined) The combined P-values were obtained using Fisher's exact test on MESA G × E GC-controlled P-values (GC P-val) and Framingham G × E P-values (P-val). All genomic locations were numbered based on Genome Reference Consortium Human Build 37 patch release 10 (GRCh37.p10).