Figure 3.

Schematic alignment of 6q16 deletions obtained using Database of genomic Variants (DGV) Custom Tracks tool (http://dgv.tcag.ca/gb2/gbrowse/dgv2_hg19/). (a) Representation of molecularly defined 6q16 deletions encompassing 6q16.2 and/or 6q16.3 sub-bands, reported here (red bars) or previously (grey bars). Previously reported deletions were characterised by DNA microarray,^{3, 13, 15, 16, 17, 18, 22, 23, 25} FISH analysis using BAC clones,²¹ or STR analysis.²⁴ *Fetal case, **overweight, ***only perinatal data were available. (b) Enlargement of the minimal critical region defined by PWS-like patients, excluding patient no. 15 from the present series and Subject 11 from Rosenfeld et al series. The region contains three genes: MCHR2, SIM1, and ASCC3.