Table 1b. Clinical characteristics of entire cohort by OI type and subdivided by age.
| OI type I | OI type III | OI type IV | |
|---|---|---|---|
| Individuals (n) | 151 | 29 | 42 |
| Gender (children, F/M) | 32/39 | 11/4 | 7/9 |
| Gender (adult, F/M) | 33/46 | 10/4 | 8/18 |
| Age baseline (children, average) | 4.49±3.28 | 0.69±0.82 | 1.13±1.06 |
| Age baseline (adult, average) | 18.77±14.64 | 17.63±19.37 | 13.63±10.25 |
| BMD baseline (SD/Z-scores, children) | −2.39±1.50 | −5.02±1.35 | −4.18±1.40 |
| BMD baseline (SD/Z-scores, adult)) | −2.96±1.35 | −5.08±2.61 | −4.33±1.81 |
| P-value | NS | NS | NS |
| Age database lock (average) | 22.37±16.86 | 22.55±18.73 | 19.64±12.04 |
| Age database lock (children) | 9.22±4.71 | 9.27±4.82 | 9.25±5.64 |
| Age database lock (adults) | 34.18±14.98 | 36.79±17.58 | 26.04±10.35 |
| Height database lock (SD/Z-scores, children) | −0.95±1.39 | −4.97±1.58 | −1.77±1.25 |
| Height database lock (SD/Z-scores, adult) | −1.18±1.38 | −9.38±2.79 | −3.04±3.06 |
| P-value | NS | <0.0001 | NS |
| Fractures database lock (per year, children) | 0.69±0.85 | 4.94±12.50 | 1.91±2.02 |
| Fractures database lock (Per year, adult) | 0.48±0.47 | 2.44±1.66 | 1.00±0.71 |
| P-value | 0.0983 | NS | 0.0691 |
| Vertebral fractures database lock (yes, children) | 65% | 100% | 82% |
| Vertebral fractures database lock (yes, adult) | 78% | 90% | 95% |
| P-value | NS | NS | NS |
Abbreviation: NS, not significant. Clinical characteristics of all 222 individuals with OI types I, III, and IV, irrespective of collagen I mutation status. Baseline BMD values are presented to avoid including bisphosphonate effects, while remaining characteristics are registered at database lock (31 December 2013), average age by OI type stated for both time points. Figures stated are averages or frequencies for each group, as appropriate. Children defined as 18 years or younger at database lock (31 December 2013).