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. 2014 Nov 12;23(8):1072–1079. doi: 10.1038/ejhg.2014.240

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Predictive value of the bioimaging tool. (a) Location of the neutral variant c.820G>A (p.Gly274Ser) and the pathogenic c.1108G>T (p.Asp370Tyr). (b) IN profiles of WT cells (blue line), cells expressing the neutral variant (green line), and the pathogenic variant (red line). (c) Typical virtual cells for WT and E-cadherin variants. (d) Quantification of E-cadherin intensity profiles. Mean fluorescence intensity±SE and MMR are presented. All results obtained in cells expressing E-cadherin variants when compared with WT cells are significantly different (Bonferroni-corrected P-value<0.017).