Table 1. Methods to Generate iPSCs.

This table summarizes the first reports of different ways to induce pluripotency, species of cells that were used, and if that method leads to transgene-free cells. This table is not an exhaustive list and is meant to be representative.

Reference	Species	Method	Transgene-free
(Takahashi and Yamanaka, 2006)	Mouse	Lentivirus	No
(Takahashi et al., 2007), (Yu et al., 2007)	Human	Lentivirus	No
(Stadtfeld et al., 2008)	Mouse	Adenovirus	Yes
(Ban et al., 2011)	Human	Sendai Virus	Yes
(Yu et al., 2009)	Human	Episomal	Yes
(Si-Tayeb et al., 2010b)	Human	Plasmid DNA	Yes
(Jia et al., 2010)	Human	Novel ‘minicircle’ DNA	Yes
(Warren et al., 2010), (Yakubov et al., 2010)	Human	mRNA transfection	Yes
(Kim et al., 2009)	Human	Protein transfection	Yes
(Montserrat et al., 2010)	Human	Poly-β-amino esters to transfect plasmids	No
(Ye et al., 2010)	Mouse and Human	Bacteriophage ΦC31 integrase	No
(Hockemeyer et al., 2008)	Human	Drug inducible lentivirus	No
(Li et al., 2010) and (Zhao et al., 2010)	Human	Lentivirus delivering only Oct4, Sox2 and Nanog	No
(Huangfu et al., 2008)	Human	Retrovirus delivering only Oct4 and Sox2 along with valproic acid treatment	No
(Montserrat et al., 2011)	Pig	Lentivirus delivering only Sox2, Klf4 and c-Myc in feeder-free conditions	No