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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Curr Protoc Toxicol. 2016 Feb 1;67:14.13.1–14.13.27. doi: 10.1002/0471140856.tx1413s67

Table 2. Summary of the Different Strategies to Increase Reprogramming Efficiencies and iPSC Colony Formation.

This table summarizes the various ways researchers have increased reprogramming efficiencies and iPSC colony formation. Table includes the specific reference associated with the method and the species of cells used. Method described in table is what is included in addition to the usual forced transcription of the reprogramming genes. This table is not an exhaustive list and is meant to be representative.

Reference Species Method
(Choi et al., 2011) Mouse miR-34 deficiency
(Angel and Yanik, 2010) Human Innate immune suppression
(Liao et al., 2008) Human Combination of six transcription factors
(Yoshida et al., 2009) Mouse and Human Hypoxia
(Lin et al., 2009) Human TGFβ and MEK-ERK pathway inhibition
(Mali et al., 2008) Human Addition of SV40 large T antigen
(Wang et al., 2011) Mouse and Human Co-expression of RAR-γ and Lrh-1
(Zhao et al., 2008) Human Addition of UTF1 forced transcription and p53 siRNA
(Kleger et al., 2012) Mouse Enrichment of the cell population for progenitor cells