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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Curr Protoc Toxicol. 2016 Feb 1;67:14.13.1–14.13.27. doi: 10.1002/0471140856.tx1413s67

Table 7. Summary of Various Reports of Disease-specific iPSC Generation.

This table is a summary of the various diseases that have had iPSCs generated from patient-specific cells. This table is not an exhaustive list and is meant to be representative.

Reference Species Disease
Liver Disease-specific Applications
(Hansel et al., 2013) Human CN-1
(Rashid et al., 2010) Human A1AT, FH, GSD, CN-1, tyrosinemia
(Ghodsizadeh et al., 2010) Human Tyrosinemia, GSD, progressive familial hereditary cholestasis, CN-1
(Yusa et al., 2011) Human A1AT
(Zhang et al., 2011) Human Wilson’s disease
Other Disease Applications
(Park et al., 2008a) Human adenosine deaminase deficiency-related severe combined immunodeficiency, Shwachman-Bodian-Diamond syndrome, Gaucher disease type III, muscular dystrophy, Parkinson disease, Huntington disease, juvenile-onset type 1 diabetes mellitus, down syndrome/trisomy 21, carrier state of Lesch-Nyhan syndrome
(Kazuki et al., 2010) Mouse and Human muscular dystrophy
(Soldner et al., 2009) Human Parkinson’s disease (transgene-free)
(Ebert et al., 2009) Human spinal muscular atrophy
(Lee et al., 2009) Human familial dysautonomia
(Meng et al., 2010) Mouse lysosomal storage disorders
(Pasca et al., 2011) Human Timothy syndrome
(Raya et al., 2009) Human Fanconi anemia
(Sebastiano et al., 2011) Human sickle cell anemia
(Dimos et al., 2008) Human Amyotrophic lateral sclerosis
(Sanchez-Danes et al., 2012) Human Genetic and sporadic Parkinson’s disease
(Lee et al., 2014) Human Rheumatoid arthritis and osteoarthritis