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. Author manuscript; available in PMC: 2017 Jan 13.
Published in final edited form as: J Am Chem Soc. 2015 Dec 28;138(1):289–299. doi: 10.1021/jacs.5b10494

Table 3.

Simulated Rates of H2S and LMW Persulfide Production at Physiologically Relevant Substrate Concentrationsa

enzyme/
reaction		 activity (µmol mg−1
h−1)		 enzyme/
reaction		 activity (µmol
mg−1 h−1)
CBS CSE
H2S from 2 0.31 H2S from 2 1.94
H2S from 3 0.032 H2S from 3 0.000002
H2S from 4 2.66 H2S from 4 0.031
Total H2S
(2 + 3 + 4)		 3.0 H2S from 5 0.0001
Cys−SSH
from 5		 0.0001 H2S from 6 0.000005
Total H2S
(2 + 3+4 +
5+6)		 1.97
Cys−SSH
from 7		 0.026
Hcy−SSH
from 8		 0.0002
a

The concentrations of the metabolites used in the simulations are given in Table 2.