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. 2015 Mar 11;23(12):1640–1645. doi: 10.1038/ejhg.2015.38

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Copyright © 2015 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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BMPR1B^K325N impacts receptor activity. Transfection of primary limb bud-derived mesenchymal cells was used to evaluate the impact of heterologous expression of either wildtype (BMPR1B^WT), mutant (BMPR1B^K325N), or control pKS on Sox-driven reporter activity (Col2-Luc). BMP4 (20 ng/ml) was added 24 h post transfection, and luciferase activity was assessed 48 h post transfection. P-values were calculated using one-way ANOVA with Tukey post-hoc test. Error bars represent 1 SD.